The Republic of Guinea signed the Mine Ban Treaty on 4 December 1997 and ratified it on 8 October 1998, becoming a State Party on 1 April 1999. Guinea has never used, produced, or exported antipersonnel mines. Guinea has not enacted new legislation specifically to implement the Mine Ban Treaty. On 24 June 2004, Guinea submitted its initial Mine Ban Treaty Article 7 report, which was due 28 September 1999, but it has not submitted subsequent annual reports. Guinea completed destruction of its stockpile of 3,174 antipersonnel mines in November 2003 and did not retain any mines for research or training purposes.

Guinea attended the Tenth Meeting of States Parties to the Mine Ban Treaty in Geneva in November–December 2010, but did not attend the intersessional Standing Committee meetings in Geneva in June 2011.

Guinea is not party to the Convention on Conventional Weapons.

Guinea is not mine-affected but areas near the border with Sierra Leone are contaminated by unexploded ordnance.